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Measurement of Phalangeal Bone Mineral Density

Principal Investigator: Tania Douglas

Dual-energy X-ray absorptiometry (DXA) is the gold standard for measuring bone mineral density (BMD) for the diagnosis and management of osteoporosis, due to low radiation dose, high accuracy and proven ability to evaluate fracture risk. We have developed and validated methods for accurate measurement of BMD in hand bones on the Lodox Statscan, using two approaches: DXA and computed digital absorptiometry (CDA). The latter is a low-cost, low radiation radiographic technique for assessing phalangeal bone mass. A new calibration phantom has been designed for DXA and a novel volumetric BMD measurement technique has been developed. We propose to develop 3D reconstruction methods that would allow volumetric BMD measurement at sites traditionally used for fracture risk assessment, such as the femur, the forearm and the spine.

Journal publications

  • Dendere R, Whiley SP, Douglas TS. Computed Digital Absorptiometry for Measurement of Phalangeal Bone Mineral Mass on a Slot-scanning Digital Radiography System, Osteoporosis International 2014, 25(11): 2625-30.
  • Dendere R, Potgieter H, Steiner S, Whiley SP, Douglas TS. Dual-energy X-ray absorptiometry for measurement of phalangeal bone mineral density on a slot-scanning digital radiography system. IEEE Transactions on Biomedical Engineering 2015, 62(12):2850-9 DOI:10.1109/TBME.2015.2447575.